Short Communication:Antifibrogenic Effects of Liposome-Encapsulated IFN-α2b Cream on Skin Wounds in a Fibrotic Rabbit Ear Model
| Autor: | Reza B. Jalili, Edward E. Tredget, Jack Demare, Jonathan P. Lee, Aziz Ghahary |
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| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Journal of Interferon & Cytokine Research. 25:627-631 |
| ISSN: | 1557-7465 1079-9907 |
| DOI: | 10.1089/jir.2005.25.627 |
| Popis: | This study was conducted to assess the ability of a dermal cream containing liposome-encapsulated interferon- α2b (IFN-α2b) (LIPO+IFN) to improve hypertrophic scarring in open and reepithelialized dermal wounds in a rabbit fibrotic ear model. Full-thickness skin wounds were made in New Zealand white rabbits, and were either left untreated, treated on day 16 postsurgery (open wound), or treated on day 23 postsurgery (reepithelialized wound) with either LIPO+IFN or liposome alone (LIPO). The conditions of the wounds were monitored until day 35 postsurgery, when hypertrophic scar formation reached its peak. Dry wound weight, scar thickness, hypertrophic index (HI), and tissue cellularity of treated and untreated wounded tissue samples were evaluated as an index for scar formation. The results of this study showed that reepithelialized wounds treated with LIPO+IFN and to a lesser extent with LIPO alone were reduced in thickness, HI, and cellularity compared with untreated control wounds or LIPO+IFN-treated op... |
| Databáze: | OpenAIRE |
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