Synthesis and in vitro cytotoxicity studies of novel triazolo[4,3-b]pyridazinones

Autor:	A. Hannioui, Nouredine Benchat, E. M. Rakib, Abdelmajid Zyad, S. Abouricha, L. Ait M’barek
Rok vydání:	2006
Předmět:	13c nmr spectroscopy Chemistry Stereochemistry In vitro cytotoxicity Regioselectivity General Chemistry Cytotoxicity In vitro Cycloaddition
Zdroj:	Journal of the Iranian Chemical Society. 3:272-276
ISSN:	1735-2428 1735-207X
DOI:	10.1007/bf03247219
Popis:	New triazolo[4,3-b]pyridazinones were synthesized and evaluated for their potential in vitro cytotoxic antitumor properties. The compounds were prepared by 1,3-dipolar cycloaddition of pyridazin-3-ones with N-aryl-C-ethoxycarbonylnitrile imines, generated in situ from ethylhydrazono-a-bromoglyoxylates. The peri- and regioselectivity of the reaction were ascertained by 1H and 13C NMR spectroscopy of the cycloadducts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9530f7fe6b6419072d32746e186ae7ac https://doi.org/10.1007/bf03247219 Zobrazit plný text záznamu Full text from SpringerLink