Influence of dearterialization on distribution of absolute tumor blood flow between hepatic artery and portal vein

Autor: Bo G. Persson, Lennart Bergqvist, Stig Bengmark, Li-Qing Wang
Rok vydání: 1994
Předmět:
Zdroj: Cancer. 74:2454-2459
ISSN: 1097-0142
0008-543X
DOI: 10.1002/1097-0142(19941101)74:9<2454::aid-cncr2820740911>3.0.co;2-f
Popis: Background. Conflicting results have been obtained regarding blood flow distribution to liver tumors. The emphasis on portal vein perfusion has had a great impact on the design of treatment protocols. Methods. Double microsphere technique with reference organ sampling was used for the measurement of hepatic artery and portal vein blood flow of an implanted liver tumor in 42 rats after permanent dearterialization and repeated dearterialization (2 hours/day) compared with untreated sham-operated controls. Results. Portal veinous blood flow constituted 16% of total tumor blood flaw and slightly increased after permanent and repeat dearterializations, though the elevation was not statistically significant as compared with sham-treatment (P> 0.05). In another 3 groups, the treatment was extended to 10 days, and tumor blood flow was measured in central and peripheral parts separately. Arterial blood flow further decreased in tumor periphery and was still lower in the tumor center (P 0.05). Furthermore, portal supply increased neither in tumor periphery nor in tumor center after both permanent and repeated dearterialization (P > 0.05). Conclusion. The authors' results showed that portal blood flow did contribute to tumor circulation, but made up only 16% of blood flow when tumors were small and declined to 4% of entire tumor blood supply when tumors became large. Portal perfusion also declined as tumors grew larger and did not compensate for the withdrawal of tumor arterial blood supply after dearterialization. Cancer 1994:74:2454-9.
Databáze: OpenAIRE
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