Manumycin Induces Apoptosis of Leukemic Stem Cells Through Down-Regulation of Bcl2

Autor:	Miaorong She, Xilin Chen, Zesheng Lu, Kunyuan Guo, Wei Lin, Yanjie He, Xin Du, Jinggao Li
Rok vydání:	2011
Předmět:	education.field_of_study Immunology Population Farnesyltransferase inhibitor Myeloid leukemia Cell Biology Hematology Pharmacology Biology medicine.disease Biochemistry Leukemia Haematopoiesis Apoptosis medicine sense organs Stem cell Clonogenic assay education
Zdroj:	Blood. 118:4738-4738
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v118.21.4738.4738
Popis:	Abstract 4738 Acute myeloid leukemia (AML) is a serious and often lethal hematopoietic malignant disease arising from stem cells. LSCs play the central role in the relapse and refractory of AML and highlight the critical need for the new therapeutic strategies to directly target the LSC population for ultimately curing leukemia. Unfortunately, very few agents have been shown to directly target the LSC population. The present studies demonstrate that manumycin, a farnesyltransferase inhibitor, resulted in viability decrease in a dose-dependent and soft agar clonogenic formation inhibition in LSCs isolated from KG1a cell line. Furthermore, manumycin induces LSC apoptosis in a dose-dependent. The molecular mechanism of manumycin mediated apoptosis is associated with down regulation of Bcl2 and Bcl-xL. In conclusion, manumycin triggers apoptosis in LSC and represents a potentially important new class of drugs for LSC-targeted therapy. Disclosures: No relevant conflicts of interest to declare.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9522757920c29fef3a67cbafb79b5f8a https://doi.org/10.1182/blood.v118.21.4738.4738 Zobrazit plný text záznamu