Diastereocontrolled reduction of cyclic β-enaminones. A new diastereoselective route to 2,6-disubstituted piperidines

Autor:	J. P. Celerier, Stéphanie Fréville, Gérard Lhommet, Vu Moc Thuy, H. Petit, Philippe Delbecq
Rok vydání:	2001
Předmět:	chemistry.chemical_classification Reduction (complexity) Ketone chemistry Organic Chemistry Drug Discovery Biochemistry Medicinal chemistry
Zdroj:	Tetrahedron Letters. 42:4609-4611
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)00770-5
Popis:	A new diastereoselective synthesis of 2,6-disubstituted piperidinic alkaloids is presented. Three natural compounds, the (−)-pinidinone 1a , the (+)-dihydropinidine 1b and the (−)-pinidinol 1c were prepared from optically pure (6 R )-6-methylpiperidin-2-one 2 . This method is based on the chemo- and diastereocontrolled reductions of an exocyclic β-enamino ketone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::951c1b3f8fae244673206d7f3ca5fc51 https://doi.org/10.1016/s0040-4039(01)00770-5 Zobrazit plný text záznamu Full Text from ScienceDirect