Colon-specific tablets containing naproxen microsponges for effective treatment of inflammatory bowel disease
| Autor: | Sneha S. Kardile, Raosaheb S. Shendge, Kishor S. Salunke, Onkar V. Wagh |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International journal of health sciences. :8419-8441 |
| ISSN: | 2550-696X 2550-6978 |
| DOI: | 10.53730/ijhs.v6ns3.8001 |
| Popis: | Naproxen is a non-steroidal anti-inflammatory drug, indicated for the relief of inflammation. The aim of the present study was to develop & optimize the microsponges based of naproxen tablet for colon specific drug delivery for enhanced therapeutic effect. Microsponges were developed by quasi emulsion solvent diffusion method. Compatibility of the drug with excipients was studied by FT-IR & DSC .Prepared microsponges were optimized in order to analyze the effects of independent variables (ratio of drug: eudragit (X1), concentration of PVA ( X2) & stirring speed (X3)) on the particle size (Y1), entrapment efficiency (Y2) and production yield (Y3) using box behnken design. Particle size (Y1), entrapment efficiency (Y2) and production yield (Y3) were the responses selected for simultaneous optimization, with the aid of Derringer’s desirability function. The optimized formulation was subjected to in vitro study. The F1 was selected as optimized formulation based on particle size of 600.75µm , entrapment efficiency of 99.32%, and production yield 94.45% . The results showed that, generally an increase in the ratio of the drug: polymer control release rate of naproxen from micro sponges. |
| Databáze: | OpenAIRE |
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