Screening of Latin American Plants for Cytotoxic Activity

Autor:	Mireya Correa, Susana Zacchino, Giselle Tamayo, Pablo N. Solis, Mahabir P. Gupta, Yelkaira Vazquez, Alberto Giménez, Angela I. Calderón, Catherine Caballero-George, Roberto Pinzón, Armando Cáceres
Rok vydání:	2006
Předmět:	Pharmacology Piper Thevetia biology Traditional medicine Pharmaceutical Science General Medicine Piperaceae Pharmacognosy biology.organism_classification Senna occidentalis Complementary and alternative medicine Drug Discovery Botany Physalis Molecular Medicine Tovomita Medicinal plants
Zdroj:	Pharmaceutical Biology. 44:130-140
ISSN:	1744-5116 1388-0209
Popis:	The SRB cytotoxicity assay was used to screen plant extracts, in a collaborative multinational OAS project involving Argentina, Bolivia, Colombia, Costa Rica, Guatemala, Nicaragua and Panama, against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines. Out of 310 species tested, 23 (7.4%) plants showed cytotoxic activity at GI50 values ≤10 µg/ml. The most active plants were Thevetia ahouai., Physalis viscosa., Piper jacquemontianum., Piper barbatum., Senna occidentalis., Tovomita longifolia., and Lippia cardiostegia.. Blepharocalyx salicifolius. and Senna occidentalis. were selectively active against one cell line, SF-268 or MCF-7, respectively. Within the framework of this project, 14 compounds have been isolated, 5 new (4 benzophenones, coumarin) and 9 known to the literature. But only the bioassay-guided fractionation of the active extract of Piper barbatum. leaves, which led to the isolation of three known compounds: (2′E., 6′E.)-2-farnesyl-1,4-benzoquinon...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::95163ffe08d87c77b3b0a2c359dab1a3 https://doi.org/10.1080/13880200600592285 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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