Long non-coding RNA XIST promotes malignant behavior of epithelial ovarian cancer
| Autor: | Zhao Youhong, Xiaoli Liu, Qing Liu, Kun Zuo, De Chen, Song Du, Yukun Zheng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
endocrine system diseases Proportional hazards model Cell growth Cell RNA Biology female genital diseases and pregnancy complications Long non-coding RNA 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Oncology Cell culture 030220 oncology & carcinogenesis medicine Cancer research Pharmacology (medical) XIST Tumor promotion |
| Zdroj: | OncoTargets and Therapy. 12:7261-7267 |
| ISSN: | 1178-6930 |
| DOI: | 10.2147/ott.s204369 |
| Popis: | Purpose This study aims to investigate the functional role of long non-coding RNA XIST in epithelial ovarian cancer (EOC). Methods Detection of XIST expression levels in EOC tissues and cell lines was done using qRT-PCR. The relationship between XIST expression and clinicopathological features of EOC patients was compared and analyzed. The cumulative survival rates were calculated using Kaplan-Meier. A Cox hazard model was used to identify risk factors for survival. Lastly, the effects of XIST on EOC cell were assessed in vitro. Results XIST was up-regulated in EOC tissues and cell lines. The expression of XIST was closely related to the tumor grade, distant metastasis, and FIGO stage in the EOC patients. The Cox regression analysis showed that high XIST expression was an independent predictor of prognosis in patients with EOC. In in vitro experiments, reducing XIST expression significantly suppressed cell proliferation, migration and invasion in EOC cells. Conclusion XIST highly expressed in the EOC and plays a role in tumor promotion, which may be a potential target for the treatment of EOC. |
| Databáze: | OpenAIRE |
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