Homocystéine, vitamine B12 et acide folique dans le déclin cognitif chez les personnes âgées
| Autor: | A. Letaef, K. Limem, Mohamed Ali Smach, J. Ben Abdallah, Leila Ben Othmen, S. Naffeti, Bassem Charfeddine |
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| Rok vydání: | 2013 |
| Předmět: |
Vitamin
medicine.medical_specialty Hyperhomocysteinemia Homocysteine business.industry General Medicine Plasma levels medicine.disease Pathophysiology law.invention chemistry.chemical_compound Endocrinology chemistry Randomized controlled trial law Internal medicine Toxicity medicine Risk factor business |
| Zdroj: | Pathologie Biologie. 61:184-192 |
| ISSN: | 0369-8114 |
| Popis: | Hyperhomocysteinemia is a risk factor for neurological diseases, but the underlying pathophysiology has not been adequately explained. Mild hyperhomocysteinemia, which is sometimes associated with a low plasma level of vitamin B9, B12 and folic acid, is responsible in the toxicity in neural cell by activating NMDA receptor. Indeed, even if vitamin supplementation has clearly proven its efficiency on lowering plasma levels of homocysteine, recent studies do not show any positive effect of vitamin therapy on cognitive function. The hypothesis that this therapy is inefficient has been recently reinforced by two randomized trials on the effects of vitamin supplementation. Several hypotheses still need to be explored: Mechanisms of homocysteine toxicity and that of total uselessness of vitamin supplementation; the possible need to complete the actual data with further, more powerful studies in order to prove the role of homocysteine in the development of neurodegenerative diseases and a clinical effect of vitamin therapy. |
| Databáze: | OpenAIRE |
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