Effects of Adrenosterone, Testosterone, and 17 β ‐Estradiol on the Gene Expression of Insulin‐Like Growth‐Factor Binding Proteins ( igfbps ) in Atlantic Salmon Smolts
| Autor: | Ingibjörg Eir Einarsdottir, Thrandur Bjornsson, Tom Ole Nilsen, Rebecca White, Jason P. Breves, Stephen D. McCormick, Ross Cairnduff |
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| Rok vydání: | 2019 |
| Předmět: |
endocrine system
medicine.medical_specialty biology Estrogen receptor biology.organism_classification Biochemistry DNA-binding protein Adrenosterone Insulin-like growth factor-binding protein chemistry.chemical_compound Vitellogenin Endocrinology chemistry Internal medicine Gene expression Genetics medicine biology.protein Salmo Molecular Biology hormones hormone substitutes and hormone antagonists Testosterone Biotechnology |
| Zdroj: | The FASEB Journal. 33 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fasebj.2019.33.1_supplement.545.8 |
| Popis: | The growth hormone (Gh)/insulin-like growth-factor (Igf) system is a key regulator of growth in teleost fishes, including salmonids. Igfs interact with a suite of binding proteins, termed Igf binding proteins (Igfbps), which modify their biological activities. Atlantic salmon (Salmo salar) express an expanded array of igfbp gene transcripts in liver, the primary site of Igfbp production. While gonadal steroids are known to impact the growth of fishes, there is little information on how androgens and estrogens affect the expression of various igfbps. In the current study, we characterized how 14-day implants of adrenosterone (OA), testosterone (T) or 17β-estradiol (E2) affected the Gh/Igf/Igfbp network in Atlantic salmon smolts. OA did not affect any of the parameters studied. There were no effects of T or E2 on body mass, plasma levels of Igf1, or hepatic igf1, igf2 or gh receptor mRNA levels. E2 stimulated hepatic estrogen receptor α mRNA levels by 17-fold, while E2 and T stimulated hepatic vitellogenin ... |
| Databáze: | OpenAIRE |
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