Enhanced Liposomal Encapsulation of Ascorbic Acid by the Liquid Crystal β-sitosteryl-β-D-glucopyranoside

Autor:	D. M. D. Samantha Dissanayake, D. N. Karunaratne, A. D. L. Chandani Perera
Rok vydání:	2015
Předmět:	Liposome food.ingredient Chromatography General Chemistry Condensed Matter Physics Ascorbic acid Lecithin Thermotropic crystal Sodium methoxide chemistry.chemical_compound food chemistry Liquid crystal Critical micelle concentration Lyotropic General Materials Science
Zdroj:	Molecular Crystals and Liquid Crystals. 613:94-102
ISSN:	1563-5287 1542-1406
DOI:	10.1080/15421406.2015.1047297
Popis:	β-Sitosteryl-β-D-glucopyranoside (LC) was synthesized by reacting penta-O-acetyl-β-D-glucopyranoside with β-sitosterol, followed by deacetylation with sodium methoxide. Both lyotropic and thermotropic liquid crystal properties were observed under polarized light. Its critical micellar concentration (CMC) was 8.5 × 10−6 M. The calculated HLB value was 6.24. Ascorbic acid was encapsulated in liposomes constructed with lecithin and cholesterol resulting in encapsulation efficiency (EE) of 44.1% and drug loading (DL) of 78%. The addition of LC to liposomes increased the EE to 63.0% and DL to 82%. Therefore, LC has good co-surfactant properties and could be used as encapsulation enhancer in liposomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::950dc255d6e81c56f4c0bf9b63304cfc https://doi.org/10.1080/15421406.2015.1047297 Zobrazit plný text záznamu