Free-radical mechanism of the antimicrobial action of xanthine oxidase and lactoperoxidase
| ISSN: | 1573-8221 0007-4888 |
|---|---|
| DOI: | 10.1007/bf00809559 |
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_________::9509ae6847a0ef9ae8bb74a9f556a66f https://doi.org/10.1007/bf00809559 |
| Rights: | CLOSED |
| Přírůstkové číslo: | edsair.doi...........9509ae6847a0ef9ae8bb74a9f556a66f |
| Autor: | Shepelev Ap, Chernavskaia Ln, Kesel'man Ev, Al'perovich Dv |
| Rok vydání: | 1992 |
| Předmět: |
chemistry.chemical_classification
biology Lactoperoxidase Substrate (chemistry) General Medicine Antimicrobial medicine.disease_cause General Biochemistry Genetics and Molecular Biology Superoxide dismutase chemistry.chemical_compound Enzyme Biochemistry chemistry medicine biology.protein Antimicrobial action Xanthine oxidase Escherichia coli |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 114:1288-1291 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00809559 |
| Popis: | The interaction between milk xanthine oxidase (XO) and lactoperoxidase (LP) in model system and antimicrobial action of these enzymes on Escherichia coli 0-111 were studied. It was shown, that bacterial superoxide dismutase (SOD), which transforms O2-. (XO-reaction product) into H2O2 (substrate of LP), is necessary for binding of the reaction sequence: XO-->LP-->antimicrobial products. It is suggested, that these enzymes unite in the protective system in intestinal infections of newborns. Bacterial SOD in this case acts as the key factor, creating the system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink