Streptococcal Toxic Shock Syndrome Associated with Marked T Cell Expansion: Case Report

Autor:	T. Schneider, Helmut Hahn, H.-U. Jahn, Mardjan Arvand
Rok vydání:	1996
Předmět:	Microbiology (medical) business.industry Streptococcus T cell Lymphocyte Erythrogenic toxin Toxic shock syndrome T lymphocyte medicine.disease_cause medicine.disease Microbiology Infectious Diseases medicine.anatomical_structure Streptococcus pyogenes Immunology medicine IL-2 receptor business
Zdroj:	Clinical Infectious Diseases. 22:362-365
ISSN:	1537-6591 1058-4838
Popis:	Streptococcal toxic shock syndrome (strepTSS) has been associated with various streptococcal soft-tissue infections including cellulitis, necrotizing fasciitis, and peritonitis in adults. We describe a 40-year-old patient with pharyngitis and strepTSS. Throat swab cultures yielded a strain of Streptococcus pyogenes that produced large amounts of erythrogenic toxin A. Fluorescence-activated cell sorter analysis of the patient's peripheral blood lymphocytes revealed generally enhanced expression of the T cell activity markers CD25 and human leukocyte antigen-DR and a marked increase in the number of gamma delta T cells, largely of the V delta 1-bearing subpopulation. Two more analyses, which were performed 2 weeks and 9 months later, respectively, documented the course of normalization after the acute episode of strepTSS. The T cells of this patient were stimulated in vitro with supernatants of his streptococcal isolate, and they proliferated in a dose-dependent manner. These proliferating T cells were mainly alpha beta T cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::95065c1f8bbedd212967ca395053aa93 https://doi.org/10.1093/clinids/22.2.362 Zobrazit plný text záznamu