The Effects of Sex and Estrogen on Radiographic Progression of Ankylosing Spondylitis in Korean Patients
| Autor: | Hyemin Jeong, Eun-Kyung Bae, Jiwon Hwang, Eun-Jung Park, Jaejoon Lee, Chan Hong Jeon, Eun-Mi Koh, Hoon-Suk Cha |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Ankylosing spondylitis 030219 obstetrics & reproductive medicine business.industry medicine.drug_class Radiography Leptin medicine.disease Gastroenterology 03 medical and health sciences Serum estrogen 0302 clinical medicine Rheumatology Estrogen Internal medicine medicine In patient business Generalized estimating equation Body mass index 030304 developmental biology |
| Zdroj: | Journal of Rheumatic Diseases. 28:76-84 |
| ISSN: | 2233-4718 2093-940X |
| DOI: | 10.4078/jrd.2021.28.2.76 |
| Popis: | Objective. Ankylosing spondylitis (AS) is a chronic inflammatory disease with obvious male preponderance. Males show more severe radiographic manifestations compared with females. This study aimed to evaluate the effects of sex and estrogen on the radiographic progression of AS. Methods. A total of 101 patients with AS were included in this study. All of the radiographs were scored using the modified Stoke AS Spine Score (mSASSS). Serum levels of 17β-estradiol (E2), dickkopf-1 (Dkk1), and leptin were detected by enzyme-linked immunosorbent assay. The generalized estimating equations model was used to evaluate factors associated with spinal radiographic progression. Results. The mean age at disease onset was 27.3±10.7 years, and 16 patients (15.8%) were female. In the multivariable analysis, body mass index (β-coefficient=0.12; p=0.047) and levels of Dkk1 (β-coefficient=-0.11; p＜0.001), and female (β-coefficient=-1.40; p=0.001) were associated with radiographic progression. Among male patients with AS, baseline C-reactive protein (β=0.11; p=0.005) and mSASSS (β=0.21; p=0.030) were also associated with radiographic progression. E2 and leptin levels were not significantly related to the radiographic progression. Conclusion. Although female patients were associated with less radiographic progression in AS, there was no significant relationship between serum estrogen level and radiographic progression. Results of current study suggests that genetic factors or other environmental factors associated with female may influence radiographic progression in patients with AS. (J Rheum Dis 2021;28:76-84) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|