Predicting small molecule binding pockets on diacylglycerol kinases using chemoproteomics and AlphaFold
| Autor: | Roberto Mendez, Minhaj Shaikh, Michael C. Lemke, Kun Yuan, Adam H. Libby, Dina L. Bai, Mark M. Ross, Thurl E. Harris, Ku-Lung Hsu |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | RSC Chemical Biology. |
| ISSN: | 2633-0679 |
| Popis: | We provide a family-wide assessment of accessible sites for covalent targeting that combined with AlphaFold revealed predicted small molecule binding pockets for guiding future inhibitor development of the DGK superfamily. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|