Activity of liver monooxygenase system in rats with low and high resistance to hypoxia

Autor:	O. R. Grek, V. I. Sharapov
Rok vydání:	1996
Předmět:	Chemistry General Medicine Monooxygenase Hypoxia (medical) Pharmacology General Biochemistry Genetics and Molecular Biology In vitro High resistance Hydroxylation chemistry.chemical_compound Nifedipine medicine Microsome medicine.symptom Diazepam medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 122:906-908
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02446578
Popis:	Rats with low and high resistance to hypoxia are shown to differ in terms of the baseline activity of liver monooxygenases bothin vivo andin vitro. Low-resistance animals are characterized by a significantly higher rate of elimination of antipyrine, hexenal, and nifedipine, as evidenced by shorter half-elimination period and higher urinary concentration of metabolites. The concentration of microsomal cytochromes P-450 and b5 as well as the rates of N-demethylation of amidopyrine, p-hydroxylation of aniline, and hydroxylation of diazepam are considerably higher in rats with low resistance to hypoxia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::94e9f5766f116b72f632ea02fe9481e3 https://doi.org/10.1007/bf02446578 Zobrazit plný text záznamu Full text from SpringerLink