DETERMINATION OF ACUTE AND SUBACUTE TOXICITY OF THE DRUG BASED ON CHLORTETRACYCLINE HYDROCHLORIDE
| Autor: | І. Ya. Kotsyumbas, I. P. Patereha, V. I. Kushnir, S. Ya. Martynyk, M. M. Chudyak, T. V. Yurynets |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology. 21:71-75 |
| ISSN: | 2664-5610 2410-9029 |
| Popis: | The article presents the results of determination of acute and subacute toxicity of the drug "Chloracil", which was made on the basis of chlortetracycline hydrochloride. In result of the conducted researches, it was found out, that a single intragastric administration of the drug according to SOU 85.2-37-736: 2011 belongs to the 4th class of toxicity - low-toxic substances. In determining the toxicity of the drug by the long-term use, it was found out, that the use of Chloracil in therapeutic and in 10 times higher than the therapeutic doses did not cause death of white rats. The animals of the experimental groups were active, ate well food , and the general condition of the animals did not differ from the condition of the animals of the control group, but there was a tendency to decrease the weights of liver, spleen, heart, lungs, thymus and kidneys on the background of an increase of body weight by 3.4 and 7.3% (p |
| Databáze: | OpenAIRE |
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