Inhibition of cartilage degradation by isothiazoloquinolinones
| Autor: | William Henry Miller, M. A. Pratta, E. C. Arner, Robert J. McHugh, Donald Joseph-Phillip Pinto, Ronald L. Magolda |
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| Rok vydání: | 1994 |
| Předmět: |
Stereochemistry
Chemistry Cartilage Organic Chemistry Clinical Biochemistry Pharmaceutical Science Benzisothiazolone Biological activity Organ culture Biochemistry Cartilage degradation Chemical synthesis In vitro Cell biology medicine.anatomical_structure Drug Discovery medicine Molecular Medicine Nasal cartilages Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 4:843-846 |
| ISSN: | 0960-894X |
| Popis: | Several aryl-fused isothiazoloquinolinones were prepared and were found to inhibit IL-1β induced degradation of bovine nasal cartilage in an organ culture assay. These compounds, derived conceptually from the benzisothiazolone ring system, represent a new, non-peptide class of inhibitors of cartilage degradation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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