Validation of FDG Uptake in the Arterial Wall as an Imaging Biomarker of Atherosclerotic Plaques with18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG-PET/CT)
| Autor: | Steve Bacharach, Monica Bucci, Carole Schrek, Max Wintermark, Randy Hawkins, Eugenio Parati, Carina Mari Aparici, S.-C. Cheng, Elizabeth Tong, Sandeep Arora |
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| Rok vydání: | 2012 |
| Předmět: |
Fluorodeoxyglucose
medicine.medical_specialty Aorta education.field_of_study medicine.diagnostic_test Imaging biomarker business.industry Whole body imaging Population Standardized uptake value Positron emission tomography medicine.artery Angiography medicine Radiology Nuclear Medicine and imaging Neurology (clinical) Radiology Nuclear medicine business education medicine.drug |
| Zdroj: | Journal of Neuroimaging. 24:117-123 |
| ISSN: | 1051-2284 |
| DOI: | 10.1111/j.1552-6569.2012.00740.x |
| Popis: | BACKGROUND AND PURPOSE From the literature, the prevalence of fluorodeoxyglucose (FDG) uptake in large artery atherosclerotic plaques shows great heterogeneity. We retrospectively reviewed 100 consecutive patients who underwent FDG-positron emission tomography-computed tomography (PET/CT) imaging of their whole body, to evaluate FDG uptake in the arterial wall. MATERIALS AND METHODS We retrospectively evaluated 100 whole-body PET-CT scans. The PET images coregistered with CT were reviewed for abnormal 18F-FDG uptake. The mean standard uptake value (SUV) was measured in regions of interest (ROIs). The prevalence of PET+ plaques was determined based on the qualitative PET review, used as the gold standard in a receiver-operating characteristic (ROC) curve analysis to determine an optimal threshold for the quantitative PET analysis. RESULTS The qualitative, visual assessment demonstrated FDG uptake in the arterial walls of 26 patients. A total of 85 slices exhibited FDG uptake within the arterial wall of 37 artery locations. 11, 17, and 2 patients exhibited FDG uptake within the wall of carotid arteries, of the aorta, and of the iliac arteries, respectively. Only 4 of the 26 patients had positive FDG uptake in more than one artery location. In terms of quantitative analysis, a threshold of 2.8 SUV was associated with a negative predictive value of 99.4% and a positive predictive value of 100% to predict qualitative PET+ plaques. A threshold of 1.8 SUV was associated with a negative predictive value of 100% and a positive predictive value of 99.4%. Area under the ROC curve was .839. CONCLUSION The prevalence of PET uptake in arterial walls in a consecutive population of asymptomatic patients is low and usually confined to one type of artery, and its clinical relevance in terms of vulnerability to ischemic events remains to be determined. |
| Databáze: | OpenAIRE |
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