Synthesis and Anticancer Evaluation of New Derivatives of 3-Phenyl-1,5-Dimethyl-1H-[1,2,4]Triazolo[4′,3′:1,2]Pyrimido[4,5-e][1,3,4]Oxadiazine

Autor:	Zahra Tayarani-Najaran, Mohammad Rahimizadeh, Seyed Hadi Mousavi, Marzieh Akbarzadeh, Ali Shiri, Mehdi Bakavoli, Hoda Atapour-Mashhad
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Carbon disulfide biology Cyanide General Chemistry biology.organism_classification Medicinal chemistry HeLa chemistry.chemical_compound chemistry MCF-7 Sulfanyl MTT assay Viability assay Alkyl
Zdroj:	Journal of Chemical Research. 34:403-406
ISSN:	2047-6507 1747-5198
DOI:	10.3184/030823410x520778
Popis:	The synthesis of new derivatives of 3-phenyl-1,5-dimethyl-1H-[1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-e][1,3,4]oxadiazines 5a–e and 7a–e is described through heterocyclisation of hydrazino derivative (3) with aromatic aldehydes or carbon disulfide and alkyl halides. [(1,5-Dimethyl-3-phenyl-1H-[1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-e][1,3,4]oxadiazin-7-yl) sulfanyl]methyl cyanide was singled out to be tested on different cancer cell lines including HeLa, MCF-7, and HepG2. Malignant cells were cultured in DMEM medium and incubated with different concentrations of the titled compounds. Cell viability was quantified by MTT assay.
Databáze:	OpenAIRE
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