Hybrid PCL/CaCO3 scaffolds with capabilities of carrying biologically active molecules: Synthesis, loading and in vivo applications
| Autor: | AK Sargsyan, M. O. Kurtukova, Anna G. Ivanova, Bogdan Parakhonskiy, G. P. Lyubun, Vsevolod S. Atkin, EI Cherevko, Mariia Saveleva, I. A. Norkin, Andre G. Skirtach, Dmitry A. Gorin, AS Fedonnikov, A V Martyukova, A. N. Ivanov |
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| Rok vydání: | 2018 |
| Předmět: |
Scaffold
Materials science technology industry and agriculture Bioengineering macromolecular substances 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Controlled release 0104 chemical sciences Biomaterials chemistry.chemical_compound chemistry Tissue engineering Mechanics of Materials In vivo Vaterite Drug delivery Polycaprolactone 0210 nano-technology Bone regeneration Biomedical engineering |
| Zdroj: | Materials Science and Engineering: C. 85:57-67 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2017.12.019 |
| Popis: | Designing advanced biomaterials for tissue regeneration with drug delivery and release functionalities remains a challenge in regenerative medicine. In this research, we have developed novel composite scaffolds based on polymeric polycaprolactone fibers coated with porous calcium carbonate structures (PCL/CaCO3) for tissue engineering and have shown their drug delivery and release in rats. In vivo biocompatibility tests of PCL/CaCO3 scaffolds were complemented with in vivo drug release study, where tannic acid (TA) was used as a model drug. Release of TA from the scaffolds was realized by recrystallization of the porous vaterite phase of calcium carbonate into the crystalline calcite. Cell colonization and tissue vascularization as well as transplantability of developed PCL/CaCO3 + TA scaffolds were observed. Detailed study of scaffold transformations during 21-day implantation period was followed by scanning electron microscopy and X-ray diffraction studies before and after in vivo implantation. The presented results demonstrate that PCL/CaCO3 scaffolds are attractive candidates for implants in bone regeneration and tissue engineering with a possibility of loading biologically active molecules and controlled release. |
| Databáze: | OpenAIRE |
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