Adenocarcinoma of The Kidney. III. Histogenesis of Renal Adenocarcinomas Induced in Rats by N-(4′-Fluoro-4-biphenylyl)acetamide234

Autor:	Melvin D. Reuber, Barry M. Heatfield, Benjamin F. Trump, Jane H. Qees
Rok vydání:	1980
Předmět:	Cancer Research medicine.medical_specialty Pathology Kidney Chemistry Nephron Hyperplasia Histogenesis medicine.disease Basophilic medicine.anatomical_structure Endocrinology Oncology Renal cell carcinoma Dysplasia Internal medicine medicine Adenocarcinoma
Zdroj:	JNCI: Journal of the National Cancer Institute. 64:1537-1545
ISSN:	1460-2105 0027-8874
DOI:	10.1093/jnci/64.6.1537
Popis:	The histogenesis of renal adenocarcinoma induced in F344 rats by the carcinogen N-(4'-fluoro-4-biphenylyl)acetamide (FBPA) was described in order to clarify the site of origin of this neoplasm within the nephron. FBPA was added to the diet up to 48 weeks, and the animals were killed at intervals from 4 to 52 weeks after initiation of the carcinogenic diet. As seen by light microscopy, tumors appeared to arise from the pars recta of the proximal tubule in a series of stages progressing from focal hyperplasia with dysplasia to development of small, then large, neoplastic nodules composed of moderately basophilic, closely packed tumor cells arranged in individual aggregates or lobules surrounded by basement membrane-like material. Karyomegaly, cystic lesions, foam cell lesions, interstitial fibrosis, and casts also accompanied tumorigenesis in this animal model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::94c71a43ea44a9855e3a3d0c9af956d1 https://doi.org/10.1093/jnci/64.6.1537 Zobrazit plný text záznamu