Experimental study of the safety of the selective COX-2 inhibitor, celecoxib, for gastric mucosa
| Autor: | Zhong Min Cui, Shi Nan Nie, Zhao Shen Li, Xian-Bao Zhan, Jun Ting Li |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Gastric gavage
medicine.medical_specialty business.industry digestive oral and skin physiology Rat model Gastroenterology digestive system diseases Lesion medicine.anatomical_structure Internal medicine Celecoxib medicine Gastric mucosa COX-2 inhibitor lipids (amino acids peptides and proteins) medicine.symptom skin and connective tissue diseases business medicine.drug |
| Zdroj: | Chinese Journal of Digestive Diseases. 4:53-56 |
| ISSN: | 1443-9611 |
| DOI: | 10.1046/j.1443-9573.2003.t01-1-00115.x |
| Popis: | OBJECTIVE: To compare the gastric mucosal damage induced by a COX-2 inhibitor, celecoxib, and a conventional NSAID, indomethacin. METHODS: A rat model of NSAID-induced gastric mucosal damage was prepared for indomethacin and celecoxib separately (n = 8). After gastric damage was induced by 100% ethanol, celecoxib was administered by gastric gavage (n = 8). Gastric mucosal concentrations of 6-keto-PGF1α and TXB2 and the lesion index (LI) were measured. Morphological changes of the gastric mucosa were assessed under light and scanning electron microscopy. RESULTS: Indomethacin caused marked gastric damage (LI: 13.38 ± 2.06) and significant reduction of the concentrations of 6-keto-PGF1α and TXB2 (P |
| Databáze: | OpenAIRE |
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