Topical amphotericin B versus subconjunctival fluconazole injection in the management of fungal keratitis
| Autor: | Ahmed A El-Hagaa, Eman F Mottawea, Saber H El-Sayed, Fareed M Wagdy |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty genetic structures business.industry Materials Science (miscellaneous) Ocular Infections 030106 microbiology Ocular trauma medicine.disease Dermatology eye diseases 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Amphotericin B 030221 ophthalmology & optometry medicine Outpatient clinic Fluconazole Injection Fungal keratitis sense organs business Fluconazole medicine.drug |
| Zdroj: | Menoufia Medical Journal. 29:601 |
| ISSN: | 1110-2098 |
| DOI: | 10.4103/1110-2098.198726 |
| Popis: | Objectives The aim of this study was to compare the use of topical amphotericin B (0.5 mg/ml) eye drops with the use of subconjunctival injection of fluconazole (2 mg/ml) in dealing with cases of fungal keratitis. Background Fungal keratitis is considered one of the serious ocular infections that lead to ocular morbidity and visual loss, especially in developing countries. Materials and methods This study was carried out on 50 eyes of 50 patients with resistant corneal ulcers attending Menoufia University Hospital outpatient clinic between July 2012 and February 2014. Results Group 1 included 25 cases treated with topical amphotericin B; the study revealed healing of corneal ulcers in six cases (24%), and 19 cases (76%) developed complications. Group 2 included 25 cases treated with subconjunctival fluconazole injection; the study revealed statistically significant result (P Conclusion and recommendations Fungal keratitis has proven to be a continually challenging ocular disease for patients, providers, and society. The most common etiologic agents have been identified to be diabetes and plant ocular trauma. Our study states that the administration of a subconjunctival injection of fluconazole was more effective compared with the administration of topical amphotericin B eye drops, as evidenced by the healing of the fungal corneal ulcer and shorter duration of healing. |
| Databáze: | OpenAIRE |
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