ChemInform Abstract: Unciaphenol, an Oxygenated Analogue of the Bergman Cyclization Product of Uncialamycin Exhibits anti-HIV Activity

Autor:	Ian Tietjen, Raymond J. Andersen, Mark A. Brockman, Julian Davies, Helen Bottriell, David E. Williams
Rok vydání:	2016
Předmět:	chemistry.chemical_compound Nucleophile chemistry Stereochemistry Diradical Bergman cyclization Enediyne Substituent Uncialamycin General Medicine In vitro Unciaphenol
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201612215
Popis:	Unciaphenol (2), an oxygenated analogue of the Bergman cyclization product of the enediyne uncialamycin (1), has been isolated along with 1 from cultures of the actinomycete Streptomyces uncialis. It is proposed that the C-22 OH substituent in 2 might arise from the attack of a nucleophilic oxygen species on the p-benzyne diradical intermediate IA in the Bergman cyclization of 1. 2 shows in vitro anti-HIV activity against viral strains that are resistant to clinically utilized anti-retroviral therapies.
Databáze:	OpenAIRE
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