In vitro cytotoxicity and genotoxicity of Furia®180 SC (zeta-cypermethrin) and Bulldock 125®SC (β-cyfluthrin) pyrethroid insecticides in human peripheral blood lymphocytes
| Autor: | Sandra Gómez-Arroyo, Josefina Cortés-Eslava, Carmen Martínez-Valenzuela, María Elena Calderón-Segura, Magdiel Sosa-López, Zaira Edtih Romero-Velázquez, Diana Flores-Ramírez, Luis Humberto Mojica-Vázquez |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pyrethroid DNA damage Health Toxicology and Mutagenesis Lymphocyte 010501 environmental sciences Cyfluthrin Toxicology medicine.disease_cause 01 natural sciences Molecular biology Cypermethrin 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology medicine.anatomical_structure chemistry medicine Trypan blue Cytotoxicity Genotoxicity 0105 earth and related environmental sciences |
| Zdroj: | Toxicology Mechanisms and Methods. 28:268-278 |
| ISSN: | 1537-6524 1537-6516 |
| DOI: | 10.1080/15376516.2017.1402977 |
| Popis: | In the present study, human peripheral blood lymphocytes were exposed in vitro to 0, 6, 12, 18, 24, and 30 μg/mL Furia®180 SC (zeta-cypermethrin) and 0, 6.3, 12.5, 18.8, 25, and 31.3 μg/mL Bulldock®125 SC (β-cyfluthrin). Exposure to 32 µg/mL bleomycin for 24 h served as a positive control. The cytotoxic and genotoxic effects of each insecticide were analyzed using alkaline comet and trypan blue dye exclusion assays. DNA damage was evaluated through three genotoxicity parameters: tail length (TL), tail moment (TM) and tail intensity (TI). Furia®180 SC and Bulldock®125 SC pyrethroid insecticides and bleomycin significantly increased DNA damage in a concentration-dependent manner. Bulldock®125 SC induced more DNA damage than Furia. Lymphocyte viability did not change after exposure to different concentrations of the two pyrethroid insecticides and bleomycin. Moreover, genotoxic results demonstrated that Furia®180 SC and Bulldock®125 SC insecticides caused in vitro DNA damage in human peripheral lymph... |
| Databáze: | OpenAIRE |
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