| Popis: |
The normal ageing process affecting the brain reduces its capacity and its reserves, thereby making it vulnerable to both internal and external insults. The major manifestation of these insults, either single or usually multiple, is delirium. Delirium significantly increases both morbidity and mortality and is a life-threatening condition. The chapter provides an overview of delirium in the very elderly. The pathophysiology of delirium remains poorly understood. The chapter reviews briefly what is known of the pathophysiology. Several theories have been proposed to explain the initial and subsequent development of delirium. The final common outcome from the many factors or mechanisms seems to be associated with alteration in the neurotransmitter synthesis and function that mediates cognitive and behavioural changes. |
