GROWTH HORMONE TREATMENT IN PRADER-LABARTH-WILLI SYNDROME
| Autor: | O Trygstad |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Muscular hypotonia medicine.diagnostic_test business.industry media_common.quotation_subject Stimulation Computed tomography Appetite Thigh Growth hormone Growth hormone treatment medicine.anatomical_structure Endocrinology Hypothalamic dysfunction Internal medicine Pediatrics Perinatology and Child Health Medicine business media_common |
| Zdroj: | Pediatric Research. 33:S40-S40 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-199305001-00221 |
| Popis: | The P-L-W syndrome is assumed to be cause by hypothalamic dysfunction. Patients have increased appetite,severe obesity, disturbed pubertal development and growth retardation,reduced sensitivity for pain, disturbed body temperatur regulation and muscular hypotonia. This study is performed on prepubertal boys and girls above 4 years of age with retared BA and sufficient energy intake. Diagnosis was based on clinical signs karyotype. Growth hormone therapy was suggested to be beneficial and the objectives were to study the effects of therapy on muscular mass, fat mobilisation and the stimulation of growth. The preliminary data from 6 patients are presented in the table. hGH dosage 0.1 IU/kg/d, max.4IU/d, given 7 d/w. The result is a great effect on growth, expressed as an increase in HV and H-SDS, a reduction in fat expressed in % (Futrex - Infrared refr.of.s.c.fat) and fat/muscle ratio in the thigh (CT scan). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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