Should Central Obesity Be an Optional or Essential Component of the Metabolic Syndrome?
| Autor: | Kenneth Hughes, Suok-Kai Chew, Chee Eng Tan, Jeannette Lee, Stefan Ma, Derrick Heng, E-Shyong Tai |
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| Rok vydání: | 2007 |
| Předmět: |
Advanced and Specialized Nursing
medicine.medical_specialty education.field_of_study business.industry Endocrinology Diabetes and Metabolism Hazard ratio Population medicine.disease Obesity Endocrinology Diabetes mellitus Internal medicine Cohort Internal Medicine medicine Metabolic syndrome Risk factor education business Cohort study |
| Zdroj: | Diabetes Care. 30:343-347 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc06-1866 |
| Popis: | OBJECTIVE—The International Diabetes Federation (IDF) proposes that central obesity is an “essential” component of the metabolic syndrome, while the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) proposes that central obesity is an “optional” component. This study examines the effect of the metabolic syndrome with and without central obesity in an Asian population with ischemic heart disease (IHD). RESEARCH DESIGN AND METHODS—From the population-based cohort study (baseline 1992–1995), 4,334 healthy individuals were grouped by the presence or absence of the metabolic syndrome and central obesity and followed up for an average of 9.6 years by linkage with three national registries. Cox’s proportional hazards model was used to obtain adjusted hazard ratios (HRs) for risk of a first IHD event. RESULTS—The prevalence of metabolic syndrome was 17.7% by IDF criteria and 26.2% by AHA/NHLBI criteria using Asian waist circumference cutoff points for central obesity. Asian Indians had higher rates than Chinese and Malays. There were 135 first IHD events. Compared with individuals without metabolic syndrome, those with central obesity/metabolic syndrome and no central obesity/metabolic syndrome were at significantly increased risk of IHD, with adjusted HRs of 2.8 (95% CI 1.8–4.2) and 2.5 (1.5–4.0), respectively. CONCLUSIONS—Having metabolic syndrome either with or without central obesity confers IHD risk. However, having central obesity as an “optional” rather than “essential” criterion identifies more individuals at risk of IHD in this Asian cohort. |
| Databáze: | OpenAIRE |
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