The role of type 1 vanilloid receptors in protective and pathological mechanisms in the stomach under the action of ulcerogenic stimuli
| Autor: | N. I. Yarushkina, T. T. Podvigina, Ludmila Filaretova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Agonist
business.industry medicine.drug_class TRPV1 Inflammation Pharmacology Transient receptor potential channel chemistry.chemical_compound Nociception medicine.anatomical_structure chemistry Capsaicin medicine Gastric mucosa lipids (amino acids peptides and proteins) medicine.symptom Receptor business |
| Zdroj: | Integrative Physiology. 2:147-156 |
| ISSN: | 2687-1270 |
| Popis: | Vanilloid receptors of type 1 (TRPV1– transient receptor potential vanilloid 1) play a key role in nociception as well as in inflammation and are a therapeutic target for the treatment of both chronic pain and a number of other pathological conditions, including cancer and cardiovascular diseases, obesity, diabetes, and intestinal inflammation. TRPV1 receptors, with capsaicin as their main agonist, are expressed by the primary afferents of capsaicin-sensitive neurons (CSN). CSN are involved in maintaining the integrity of the gastric mucosa under the action of ulcerogenic stimuli. CSN may be compared to an “alarm system” that immediately activates gastroprotective mechanisms. CSN is activated via TRPV1 receptors. This review analyzes the data on the involvement of CSN and TRPV1 stomach receptors in both protective and pathological mechanisms under the action of ulcerogenic stimuli. Our special focus is on the comparison of experimental data obtained using various approaches, including activation and deactivation of TRPV1 receptors. The paper also discusses the data on the interaction of CSN and glucocorticoids in maintaining the integrity of the gastric mucosa. The results obtained by the authors indicate the involvement of glucocorticoids in the gastroprotective effect of CSN. They also demonstrate compensatory protective role of glucocorticoids in maintaining the integrity of the gastric mucosa under CSN deactivation. |
| Databáze: | OpenAIRE |
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