Drug-induced tolerance: the effects of antibiotic pre-exposure in Stenotrophomonas maltophilia
| Autor: | Maria L A S Pereira, Kênia Valéria dos Santos, Mariana Am Ferreira |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Minimum bactericidal concentration biology medicine.drug_class business.industry Antibiotics Ceftazidime biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Microbiology Minimum inhibitory concentration Stenotrophomonas maltophilia Levofloxacin medicine bacteria Vancomycin Daptomycin business medicine.drug |
| Zdroj: | Future Microbiology. 15:497-508 |
| ISSN: | 1746-0921 1746-0913 |
| DOI: | 10.2217/fmb-2019-0253 |
| Popis: | Aim: To investigate if the prior use of nontargeted antibiotics induces cross-tolerance in Stenotrophomonas maltophilia. Methods: Antibiotic induction was performed to evaluate daptomycin and vancomycin as possible tolerance-inducing drugs measured by minimum bactericidal concentration/minimum inhibitory concentration (MIC) ratio, adapted disk-diffusion tests and time–kill curves. Results: After antibiotic exposure, three potentially tolerant strains were isolated, maintaining the same MIC value of levofloxacin, with minimum bactericidal concentration/MIC ratio slightly higher than the parental. In the adapted disk-diffusion test, one strain (D25) showed high tolerance level for levofloxacin, ceftazidime and ticarcillin-clavulanate. In time–kill activity of levofloxacin, D25 presented a subpopulation of persisters with survival rate higher (1.6-fold) than the parental. Conclusion: Previous exposure of S. maltophilia to daptomycin can induce cross-tolerance to ceftazidime and ticarcillin-clavulanate and cross-persistence to levofloxacin. |
| Databáze: | OpenAIRE |
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