Immunonanoparticles for targeting and delivery of protein drugs into tumour cells

Autor:	Jernej Kristl, Janko Kos, Petra Kocbek, Mateja Cegnar, Nataša Obermajer
Rok vydání:	2008
Předmět:	Proteases medicine.drug_class Pharmaceutical Science Biology Endocytosis Monoclonal antibody Molecular biology Cathepsin B Biochemistry Antigen medicine Cystatin Intracellular Cysteine
Zdroj:	Journal of Controlled Release. 132:e60-e61
ISSN:	0168-3659
DOI:	10.1016/j.jconrel.2008.09.057
Popis:	Cystatin, a protein inhibitor of cysteine proteases with potential antitumoural activity, was incorporated in poly(lactide-co-glycolide) nanoparticles, which were further surface-modified with monoclonal antibody, recognizing specific antigen overexpressed on invasive breast tumour cells (MCF-10A neoT). Results showed that immunonanoparticles were able to recognize and target the antigen on MCF-10A neoT cells in a co-culture with other cells. Following endocytosis, cystatin delivered by immunonanoparticles (immuno-NPs), effectively inhibited intracellular cathepsin B only in the target cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::946ea1b46875f32eb667d0981ec86f13 https://doi.org/10.1016/j.jconrel.2008.09.057 Zobrazit plný text záznamu Full Text from ScienceDirect