| Popis: |
Pediatric deep and cutaneous vascular lesions (hemangiomas) and vascular malformations, having been confused by many clinicians for decades, have been finally classified accurately by Mulliken, Glowacki, and coworkers, after denovo research into endothelial cell characteristics, numbers of mast cells present, and endothelial cell in vitro characteristics [1–6]. Most pediatric hemangiomas are not present at birth, clinically manifest within the first month of life, and exhibit a rapid growth phase in the first year of life. More than 90% of pediatric hemangiomas spontaneously regress to near-complete resolution by 5–7 years of age. Hemangiomas occur with a reported incidence of 1–2.6% [1, 6, 7]. Hemangiomas in the proliferative phase are characterized by rapid growth, significant endothelial cell hyperplasia forming syncytial masses, thickened endothelial basement membrane, ready incorporation of tritiated thymidine into the endothelial cells, and the presence of large numbers of mast cells [1–3]. |
