The role of immunohistochemical adrenomedullin and Bcl-2 expression in development of type-1 endometrial adenocarcinoma
| Autor: | Kemal Kürşat Bozkurt, Nilgun Kapucuoglu, İbrahim Metin Çiriş, Burak Tatar, Ebru Erdemoğlu, Afife Uğuz, Sevim Süreyya Çerçi, Evrim Erdemoglu, Yakup Yalcin, Şirin Başpınar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endometrial intraepithelial neoplasia business.industry Cancer Cell Biology medicine.disease Endometrium Pathology and Forensic Medicine Endometrial hyperplasia Adrenomedullin 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis Internal medicine medicine Carcinoma Cancer research Adenocarcinoma Simple Endometrial Hyperplasia business |
| Zdroj: | Pathology - Research and Practice. 212:450-455 |
| ISSN: | 0344-0338 |
| Popis: | Background Adrenomedullin (AM) is a pluripotent peptide first discovered from human pheochromocytoma. AM expression has been shown in various cancer types including endometrium cancer. Bcl-2 is an antiapoptotic protein which might be regulated by AM in hypoxic conditions. The aim of the present study was to investigate the role of AM and Bcl-2 expressions in carcinogenesis of type-1 endometrium cancer. Materials and method Study group consisted of 10 proliferative endometrium, 22 simple endometrial hyperplasia, 23 endometrial intraepithelial neoplasia (EIN) and 30 Grade 1 endometrioid adenocarcinoma patients. AM and Bcl-2 expressions were investigated by immunohistochemistry. Results Mean AM Allred score was 3 ± 2.6, 5.6 ± 1.6 and 5.7 ± 2.5 in benign, EIN and adenocarcinoma groups, respectively. AM expression was significantly higher in EIN and adenocarcinoma groups than in benign endometrium group ( p p > 0.05). However, it was significantly lower in adenocarcinoma group ( p r : −0.4, p Conclusions Our findings showed that AM expression increased in progression from benign endometrium to EIN and type-1 adenocarcinoma while expression of Bcl-2 decreased in transition from EIN to carcinoma. |
| Databáze: | OpenAIRE |
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