White adipocytes transdifferentiation into brown adipocytes induced by triiodothyronine
| Autor: | M. Grubic, Mirela Ukropina, Bato Korac, V.M. Petrović, Biljana Buzadzic, Aleksandra Jankovic, Ana Vasilijević, Aleksandra Korac, K. Micunovic, Maja Cakic-Milosevic |
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| Rok vydání: | 2008 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Triiodothyronine Transdifferentiation Adipose tissue 030209 endocrinology & metabolism White adipose tissue Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology medicine.anatomical_structure chemistry Adipogenesis Adipocyte Internal medicine Brown adipose tissue medicine Transcriptional regulation 030304 developmental biology |
| Zdroj: | EMC 2008 14th European Microscopy Congress 1–5 September 2008, Aachen, Germany ISBN: 9783540852278 |
| DOI: | 10.1007/978-3-540-85228-5_62 |
| Popis: | The uncontrolled expansion of white adipose tissue (WAT) seen in obesity predisposes affected individuals to health complications. Another type of fat, brown adipose tissue (BAT) has an opposing physiological function because it allows dissipation instead of storage of energy. Recent studies on the transcriptional control of adipocyte differentiation offer a new perspective on conversion between brown and white adipocytes. The ability of the adipose organ to interconvert its main cytotypes in order to meet changing metabolic needs is highly pertinent to the physiopathology of obesity and related to therapeutic strategies [1]. Thyroid hormones (TH) have an important role in modulation of brown adipose tissue (BAT) thermogenic function. The main objective of this work was to investigate capability of triiodothyronine to induce structural and functional changes of rat white adipocytes in retroperitoneal white adipose tissue (RWAT). |
| Databáze: | OpenAIRE |
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