Role of Gibberellic and Indole Acetic Acid in Altering Ocular Structure and Function of Mother Rats and their Offspring
| Autor: | Hassan I. El-Sayyad, A. M. A. Asiri, Mohamed E El-Beeh, M. M. Ramadan, M. H. Abou-Egla |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Environmental Engineering Antioxidant Offspring medicine.medical_treatment Biology Malondialdehyde Industrial and Manufacturing Engineering Superoxide dismutase chemistry.chemical_compound Endocrinology Biochemistry chemistry Catalase Internal medicine medicine biology.protein DNA fragmentation Gibberellic acid Hormone |
| Zdroj: | British Journal of Medicine and Medical Research. 10:1-14 |
| ISSN: | 2231-0614 |
| DOI: | 10.9734/bjmmr/2015/19964 |
| Popis: | Recently, plant growth hormones have been widely used in green houses and the consumptions of agriculture food products have markedly increased; however their toxicological aspects are still unclear. The aim of the present study is to illustrate the toxicities of plant growth hormones; gibberellic (GA3) and indole acetic acid (IAA) on ocular tissues of pregnant Wistar albino rats and their offsprings. Intra-gastric administration of either GA3 or IAA (100 mg/kg body weight) to mother rats were carried out for one month prior to conception as well as throughout gestation period (n=20). The control received saline-free organochemical compounds (n=10). At parturition, mother rats and their offsprings were sacrificed by light anesthesia, and their ocular regions were separated and investigated for light and transmission electron microscopy, immunochemical staining of Caspase-3, Bcl-2 and p53 and assessments of antioxidant enzymes and DNA fragmentation. Maternal administration of either GA3 or IAA was found to develop cataractous |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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