Antiradical and Antimicrobial Activity of Thiosemicarbaside and 1,2,4-Triazole Derivatives of Hydroxybenzoic Acid
| Autor: | S. B. Akhmetova, O. A. Nurkenov, Zh. B. Satpaeva, Z. T. Shulgau, S. D. Fazylov, M. Zh. Burkeev |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Hydroxybenzoic acid Antioxidant 010405 organic chemistry DPPH medicine.medical_treatment Organic Chemistry 1 2 4-Triazole Ascorbic acid Antimicrobial 01 natural sciences Biochemistry 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry medicine Bioorganic chemistry Antibacterial activity Nuclear chemistry |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 46:537-541 |
| ISSN: | 1608-330X 1068-1620 |
| DOI: | 10.1134/s1068162020040172 |
| Popis: | The antimicrobial and antioxidant activity of synthesized biologically active compounds have been evaluated in comparison with the standard antioxidant, ascorbic acid. The antioxidant activity of the compounds has been studied by their ability to interact with the 2,2-diphenyl-1-picrylhydrazyl radical ( $${\text{DPP}}{{{\text{H}}}^{\centerdot }}$$ ). The proposed test system has revealed the pronounced antiradical activity of 2-(2-hydroxybenzoyl)-N-phenylhydrazinecarbothioamide (1) (IC50(DPPH) = 15.5 μM) and 2-(4-hydroxybenzoyl)N-phenylhydrazinecarbothiamide (2) (IC50(DPPH) = 31.7 μM). A weak antibacterial activity of these compounds has been shown against gram-positive and gram-negative test strains. |
| Databáze: | OpenAIRE |
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