Serum cytokine TNF-alpha and hemoglobin levels in Plasmodium falciparum malaria – A correlative study in coastal districts of Odisha
| Autor: | P. C. Mohapatra, R. K. Dalai, Anshuman Sarangi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
biology
business.industry Anemia medicine.medical_treatment Plasmodium falciparum Hemoglobin levels medicine.disease biology.organism_classification Serum cytokine Cytokine parasitic diseases Immunology Genetics medicine Animal Science and Zoology Tumor necrosis factor alpha Hemoglobin business Malaria |
| Zdroj: | Apollo Medicine. 9:292-296 |
| ISSN: | 0976-0016 |
| DOI: | 10.1016/j.apme.2012.08.003 |
| Popis: | Background and objectives This study was conducted to assess the correlation between TNF alpha levels and Hemoglobin in patients affected by Plasmodium falciparum along with sex and age matched healthy controls. Methods This study included 32 patients of P. falciparum malaria, and 30 age and sex matched healthy controls. Blood samples were drawn from malaria patients admitted to medicine ward along with healthy controls and transferred to the Biochemistry department for the routine hematological parameters and ELISA for TNF-alpha, IL-12 and IL-4. Results The levels of TNF-alpha were significantly elevated in falciparum malaria compared to healthy controls. Further Hb levels in Pf malaria showed significant decline compared to healthy controls. A strong negative correlation was observed between TNF-alpha and Hb levels in Pf malaria. Conclusion The results indicate that in falciparum are characterized by up regulation of TNF-alpha and down regulation of Hb levels. Present study shows close association between severe anemia and high TNF-alpha levels. |
| Databáze: | OpenAIRE |
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