EXPRESSION OF LAMININ AND CADHERIN ASSOCIATED WITH LIVER METASTASIS IN HUMAN COLORECTAL CANCER -AN APPROACH FROM IMMUNOHISTOCHEMISTRY

Autor:	Yasushi Kaneko, Yoji Yamazaki, Kenji Ikeuchi, Yoshihiko Takao, Ken Etoh, Michiaki Watanabe, Toru Fujikawa, Sadao Anazawa, Masaichi Ogawa
Rok vydání:	2000
Předmět:	Pathology medicine.medical_specialty biology Colorectal cancer business.industry Cadherin Significant difference medicine.disease Metastasis Metachronous metastasis Laminin medicine biology.protein Immunohistochemistry business Positive staining
Zdroj:	Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association). 61:1135-1139
ISSN:	1882-5133 1345-2843
DOI:	10.3919/jjsa.61.1135
Popis:	The significance of laminin and cadherin expression in human colorectal cancer was investigated by immunohistochemical assay, and its correlation with liver metastasis was analyzed. In the synchronous metastasis group, 17 of 34 cases (50%) showed positive staining of laminin, 14 (41%) of cadherin, and 5 (14%) a decreased rate of cadherin. In the metachronous metastasis group, 17 of 30 (57%) showed positive staining of laminin, 12 (40%) of cadherin, and 6 (20%) a decreased rate of cadherin. In a control group (free of disease for 5 years), in spite of no significant differences in clinicopathological factors compared with the other two groups, only 2 of 37 cases (5%) showed positive staining of laminin, 8 (22%) in cadherin, and 2 (5%) a decreased rate of cadherin. Thus, the metastatic groups were significantly higher than the control group in expression of laminin, but no significant difference in expression of cadherin was observed. These findings suggest that laminin is a useful parameter for predicting liver metastasis.
Databáze:	OpenAIRE
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