Physiological concentrations of endothelin-1 cause only coronary vasodilatation in anesthetized rats
| Autor: | Medvedeva Na, Medvedev Os, Grafov Ma |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Myocardial ischemia business.industry Coronary vasodilatation General Medicine Endothelin 1 General Biochemistry Genetics and Molecular Biology Coronary circulation medicine.anatomical_structure Internal medicine Total dose medicine Vascular resistance Cardiology business Endothelin receptor |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 120:661-664 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Various concentrations of the peptide endothelin-1 were tested for their effect on coronary vascular resistance in anesthetized rats. Intracoronary infusion of this peptide over 4 min in a total dose that gave rise to blood concentrations of 0.002–0.003 or 0.2–0.3 fmol/ml elicited only a decrease in the estimated coronary vascular resistance. It is suggested that only supraphysiological doses of endothelin are likely to exert a powerful vasoconstrictive effect on coronary vessels and cause myocardial ischemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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