A Facile One-Pot Synthesis of 1-Substituted Tetrazole-5-thiones and 1-Substituted 5-Alkyl(aryl)sulfanyltetrazoles from Organic Isothiocyanates

Autor:	Yong-Joo Kim, Je Woo Lee, Young Soo Gyoung, Hee Jung Kim, Soon W. Lee, Sam Yong Han
Rok vydání:	2012
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Aryl Isothiocyanate One-pot synthesis Pyridine Halide Organic chemistry Molecule Tetrazole General Chemistry Alkyl
Zdroj:	Bulletin of the Korean Chemical Society. 33:55-59
ISSN:	0253-2964
DOI:	10.5012/bkcs.2012.33.1.55
Popis:	Treatments of organic isothiocyanates (R-NCS) with NaN3 in the presence of pyridine in water at room temperature gave corresponding various organic tetrazole-thiones, [S=CN4(R)] (R = alkyl or aryl). Isolated products are obtained as white or yellow solids in good yields (76-97%). The molecular structure by X-ray diffraction study for one of products shows the proposed formation. In addition, one-pot synthesis of 1substituted 5-alkyl(or aryl)sulfanyltetrazoles has been demonstrated. Addition of alkyl or aryl halides into the mixture of organic isothiocyanates, NaN3, and pyridine in water at room temperature exclusively formed 1substituted 5-alkyl(or aryl)sulfanyltetrazoles (S-derivatives) in high yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::943b61cc2210cb456117f7eec75d5384 https://doi.org/10.5012/bkcs.2012.33.1.55 Zobrazit plný text záznamu