Is there any place for a wait-and-see policy in stage I0 follicular lymphoma?
| Autor: | Trojani M, Pierre Richaud, B. Hærni, P. Soubeyran, H. Eghbali, Françoise Bonichon |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry medicine.medical_treatment Follicular lymphoma Lymph node biopsy Hematology medicine.disease Single Center Surgery Radiation therapy Oncology Follicular phase medicine Stage (cooking) Prospective cohort study business Survival rate |
| Zdroj: | Annals of Oncology. 7:713-718 |
| ISSN: | 0923-7534 |
| Popis: | Summary Background A wait-and-see policy (WS) does not appear to modify the long-term prognosis of advanced-stage follicular lymphomas (FL), while irradiation of limited stages some times causes complications and does not avert distant relapses. Consequently, we decided to test WS in a selected su bset of the localized FL, i.e., patients in complete remission (CR) after the initial lymph node biopsy (stage I0). Patients and methods Forty-three previously untreated patients were diagnosed with stage I0 FL and 26 of them were included in the WS. Their median age was 60.3 years; 19 were male and 24 female. All histological slides were reviewed and confirmed the diagnosis of FL. Median followup was 6.3 years (y). Results Thirteen of the 26 untreated patients are still relapse-free, while six relapsed locally only (median: 4.2 years after diagnosis), and reattained CR with radiotherapy. Seven patients relapsed at distant sites (median: 1 year after diagnosis). No localized relapses were observed in the treated group, but there were 7 distant relapses. Conclusions The use of use in stage I0 FL did not appear to modify the prognosis of these patients. Furthermore, we observed two distinct patterns of relapse (local and distant) that are difficult to differentiate at onset. |
| Databáze: | OpenAIRE |
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