2-Ethynylperylene and improved synthesis of 3-ethynylperylene
| Autor: | Anton V. Glybin, Alexey V. Ustinov, Vladimir A. Korshun, Alexey A. Chistov, Sergey V. Kutyakov, Ilya O. Aparin, I. V. Mikhura |
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| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Fluorescence spectra Fluorescence 0104 chemical sciences chemistry.chemical_compound Yield (chemistry) Drug Discovery Organic chemistry 3-ethynylperylene Nucleoside Friedel–Crafts reaction Perylene |
| Zdroj: | Tetrahedron Letters. 57:1003-1005 |
| ISSN: | 0040-4039 |
| Popis: | 3-Ethynylperylene 1 , an important precursor for fluorescent dyes, fluorescent nucleosides, and potent nucleoside-based antivirals, has been prepared from perylene on a multigram scale (3 steps, 55% overall yield). A simple synthesis of 2-ethynylperylene 2 from perylene (5 steps, 20% yield) has been developed. UV and fluorescence spectra of the ethynylperylenes 1 and 2 are compared to those of perylene. |
| Databáze: | OpenAIRE |
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