Historical Overview and General Methods of Membrane Potential Imaging

Autor: Lawrence B. Cohen, Oliver Braubach, Yunsook Choi
Rok vydání: 2015
Předmět:
Zdroj: Advances in Experimental Medicine and Biology ISBN: 9783319176406
DOI: 10.1007/978-3-319-17641-3_1
Popis: Voltage imaging was first conceived in the late 1960s and efforts to find better organic voltage sensitive dyes began in the 1970s and continue until today. At the beginning it was difficult to measure an action potential signal from a squid giant axon in a single trial. Now it is possible to measure the action potential in an individual spine. Other chapters will discuss advances in voltage imaging technology and applications in a variety of biological preparations. The development of genetically encoded voltage sensors has started. A genetically encoded sensor could provide cell type specific expression and voltage recording (see Chap. 20).
Databáze: OpenAIRE