AMEBA: An acid sensitive aldehyde resin for solid phase synthesis
| Autor: | Adam M. Fivush, Timothy M. Willson |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
Organic Chemistry technology industry and agriculture Cleavage (embryo) Biochemistry Reductive amination Aldehyde chemistry.chemical_compound Solid-phase synthesis stomatognathic system chemistry Acid sensitive Yield (chemistry) parasitic diseases Drug Discovery Organic chemistry Polystyrene |
| Zdroj: | Tetrahedron Letters. 38:7151-7154 |
| ISSN: | 0040-4039 |
| Popis: | Oxidation of 4-(3-methoxy-4-hydroxymethylphenoxy)methyl polystyrene resin produced AMEBA resin 1 , a novel acid sensitive aldehyde resin. Reductive amination of AMEBA resin generated resin bound amines which were derivatized as sulfonamides, amides, ureas, and carbamates. Cleavage of the resin under mild acidic conditions generated the derivatized amines in high purity and moderate yield. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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