Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo

Autor:	John T. Randolph, Matthew J. O’Connor, Fei Han, Charles W. Hutchins, Y. Amy Siu, Min Cho, Yunan Zheng, Jonathan A. Hickson, Jana L. Markley, Vlasios Manaves, Mikkel Algire, Kenton A. Baker, Alex M. Chapman, Sujatha M. Gopalakrishnan, Sanjay C. Panchal, Kelly Foster-Duke, DeAnne F. Stolarik, Anita Kempf-Grote, Darby Dammeier, Stacey Fossey, Qi Sun, Chaohong Sun, Yu Shen, Michael J. Dart, Warren M. Kati, Albert Lai, Ari J. Firestone, Michael E. Kort
Rok vydání:	2023
Předmět:	Drug Discovery Molecular Medicine
Zdroj:	Journal of Medicinal Chemistry. 66:3852-3865
ISSN:	1520-4804 0022-2623
DOI:	10.1021/acs.jmedchem.2c01415
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::941bc4bfb75cae4284f6cb7de0cad715 https://doi.org/10.1021/acs.jmedchem.2c01415 Zobrazit plný text záznamu