Adiponectin resistance in skeletal muscle: pathophysiological implications in chronic heart failure
| Autor: | Tahnee Sente, An M. Van Berendoncks, Christiaan J. Vrints, Vicky Y. Hoymans |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Adiponectin business.industry Skeletal muscle 030204 cardiovascular system & hematology medicine.disease Pathophysiology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology medicine.anatomical_structure Mitochondrial biogenesis Physiology (medical) Internal medicine Heart failure Medicine Orthopedics and Sports Medicine cardiovascular diseases medicine.symptom business Complication Wasting Resistance Process |
| Zdroj: | Journal of Cachexia, Sarcopenia and Muscle. 7:261-274 |
| ISSN: | 2190-5991 |
| DOI: | 10.1002/jcsm.12086 |
| Popis: | Skeletal muscle wasting is a common complication of chronic heart failure (CHF) and linked to poor patient prognosis. In recent years, adiponectin was postulated to be centrally involved in CHF-associated metabolic failure and muscle wasting. This review discusses current knowledge on the role of adiponectin in CHF. Particular emphasis will be given to the complex interaction mechanisms and the intracellular pathways underlying adiponectin resistance in skeletal muscle of CHF patients. In this review, we propose that the resistance process is multifactorial, integrating abnormalities emanating from insulin signalling, mitochondrial biogenesis, and ceramide metabolism. |
| Databáze: | OpenAIRE |
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