| Popis: |
A simple, practical, and efficient approach to new series of imidazole containing bisazetidinones ( and ) was prepared by Staudinger [2 + 2] cycloaddition reaction, and bisthiazolidinones ( and ) were obtained by cyclization of bisimines with thioglycolic acid. The bisimines ( and ) were synthesized by the condensation of 3-(1-(3-aminobenzyl)-4, 5-dihydro-1H-imidazol-2-yl) aniline (, ) with a series of different substituted aromatic aldehydes. All the newly synthesized target compounds were evaluated for their in vitro antimicrobial activity against two Gram-positive bacteria and two Gram-negative bacteria. Additionally, these synthesized compounds were tested for their antifungal activities. Few compounds showed very good antibacterial and antifungal activity. |
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