Investigation into the reaction of 2-amino-4,5-dimethylthiophene-3-carboxamide with iso(and isothio)cyanates under microwave irradiation

Autor:	Niloofar Tavakoli-Hoseini, Hoda Atapour-Mashhad, Mohammad Rahimizadeh, Abolghasem Davoodnia
Rok vydání:	2009
Předmět:	Solvent chemistry.chemical_compound medicine.drug_class Chemistry Heteroatom Microwave irradiation medicine Organic chemistry Carboxamide General Chemistry Medicinal chemistry Acetamide
Zdroj:	Heteroatom Chemistry. 20:346-349
ISSN:	1098-1071 1042-7163
DOI:	10.1002/hc.20557
Popis:	The reaction of 2-amino-4,5-dimethyl- thiophene-3-carboxamide with iso(and isothio) cyanates for the synthesis of thieno[2,3-d]pyrimidines has been investigated. The reactions under microwave irradiation in the presence of N,N-dimethyl acetamide as solvent gave 5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5,6-dimethyl-2-thioxo-2,3-dihy- drothieno[2,3-d]pyrimidin-4(1H)-one, and 2-aryla- mino-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one derivatives. These reactions probably proceed through intermediates 4,5-dimethyl-2-substitutedcarbamoth- ioylaminothiophene-3-carboxamides. Two of these intermediates were isolated. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:346–349, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20557
Databáze:	OpenAIRE
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