Studies toward the enantioselective synthesis of neurymenolide A: Construction of the macrocyclic core via Claisen rearrangement
| Autor: | Shohei Aiba, Tetsuji Murase, Natsuki Sakurai, Masahiro Masuda, Yusuke Ogura, Naoki Mori, Hidenori Watanabe, Tsuneomi Kawasaki, Hirosato Takikawa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
biology
010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Enantioselective synthesis Neurymenia fraxinifolia biochemical phenomena metabolism and nutrition 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Claisen rearrangement Drug Discovery Enterococcus faecium |
| Zdroj: | Tetrahedron Letters. 61:151825 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2020.151825 |
| Popis: | Neurymenolides, α-pyrone macrolides isolated from the Fijian red alga Neurymenia fraxinifolia, are anti-methicillin-resistant Staphylococcus aureus and anti-vancomycin-resistant Enterococcus faecium compounds. In this study, the macrocyclic core of neurymenolide A was constructed in an enantioselective manner by employing Claisen rearrangement as the key step. |
| Databáze: | OpenAIRE |
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